Cellulose based polymers in development of amorphous solid dispersions
نویسندگان
چکیده
منابع مشابه
Characterization of Olanzapine – Solid dispersions.
Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of Olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. Characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...
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Amorphous solid dispersions (ASDs) have been extensively exploited as a strategy for improving the dissolution performance of poorly water-soluble drugs. However, factors underpinning the observed dissolution profiles are not clearly understood, and the choice of polymeric carriers is largely empirical. In the current study, the dissolution performance of a high drug loading ASD containing the ...
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15 صفحه اولCharacterization of Olanzapine – Solid dispersions.
Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of Olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. Characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...
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The present research was aimed to develop the meclizine hydrochloride-polyethylene glycol 20000 solid dispersions to enhance the solubility and dissolution rate. They were prepared using solvent evaporation method and evaluated for solubility studies, drug-carrier compatibility studies and in vitro dissolution studies. From the solubility studies, formulation F4 was selected to prepare the fast...
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ژورنال
عنوان ژورنال: Asian Journal of Pharmaceutical Sciences
سال: 2019
ISSN: 1818-0876
DOI: 10.1016/j.ajps.2018.09.003